Recent research efforts the both Northwestern University in Chicago and also University of Pittsburgh The hospital have described work on the use of a new nanofiber gel supplying cartilage growth in knees.
The material is injected within the damaged joint and offers bone marrow stem cells to produce natural cartilage.
The nanofibers allow set up cells from bone marrow for developing cartilage containing type II bovine collagen and repair a scored joint.
Type II collagen is going to be major protein component in your articular cartilage, the gristle that caps the ends of long bones well placed joint.
This is distinctly totally different from the Type I collagen produced effect of another procedure used to signify heal cartilage damage also known as microfracture. Microfracture is surgery where small holes are instilled in the bone beneath the field of cartilage damage. Leading to bleeding from the your bones marrow.
Ostensibly, stem cells his own marrow create new cartilage material.
Microfracture causes the output of cartilage having predominately sort of I collagen. Type I collagen is going to be type found most commonly in scar tissue formation.
Type II collagen will now be weaker than Type I collagen and in all probability does not hold up as well. This may be one the reason why microfracture surgery has had trouble as first thought.
Another type of tactic called autologous chondrocyte transplantation has been used. In this tactic, cartilage is harvested from a non-weight-bearing an area of the joint. The cartilage will be specially treated in a laboratory so that individual cartilage cells duplicate. The cartilage cells are then put included with the joint under a really low flap of tissue that's sewn into place. Recovery is long together with the cartilage produced also seems to be contain mostly Type I WANT collagen.
Mosaicplasty where multiple cartilage plugs are installed in the cartilage defect has also been used. Results are wide-ranging.
Stem cell treatment your appeal of being absolutely no invasive and requiring less peace and quiet. However, controlled data to work as nonexistent. Supportive evidence experiences case studies and small numbers.
One issue that activities plagued researchers and clinicians alike is most likely the mechanical forces present within weight-bearing joints very similar to the hip and knee.
When asked his opinion the majority of nanofiber issue, Dr. Chelsea Arnold, a Chicago-based rheumatologist released, "This isn't the initial 'cartilage growth stimulator'... and furthermore it will be the last. There's no way that cartilage regrows on the top medial femoral condyle (of the knee) without a mechanical correction accompanying the particular "regrowth". The shear compression forces across the nation medial compartment are formidable... and would quickly chewing any flimsy cartilage surface come to grow on the top condyle. "
Dr. Nathan Wei, a rheumatologist specializing in stem cell treatment that osteoarthritis, concurs with Glide. Arnold to a reveal. He states, "The impact loading forces on weight-bearing joints very similar to the knee and hip are one thing to contend with but with the hip there is undoubtedly a added stress of rotational movement and the knee there feel the gliding and rotational forces to handle as well. "
He believes though, "Animal models point out that stem cell procedures are competent. And while human results are sparse, early evidence supports further investigation... I do agree that mechanical forces to help be dealt with through various means inside allow stem cells to achieve 'take'. We are currently fitting in with address this issue. Our results to date are very encouraging. "
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